Treatment of Cushing's Syndrome (2) While most cases of Cushing's syndrome respond dramatically well to treatment, a few cases remain very difficult to diagnose precisely and can be difficult to treat satisfactorily. The management of this condition often still presents a most difficult clinical challenge. See later: • Cushing's Syndrome – Surgery • Cushing's Disease – Transsphenoidal Surgery • Cushing's Syndrome – Adrenalectomy • Cushing's Syndrome – Radiotherapy • Cushing's Syndrome – Metyrapone Therapy • Cushing's Syndrome – Ketoconazole Therapy